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Animal studies demonstrate that IGF-1 treatment reduces circulating free fatty acid levels, potentially through increased muscle uptake and oxidation combined with reduced adipose tissue lipolysis

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van Osch GJ, et al

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In a long-term evaluation of the LEADER trial with 9,340 patients with T2D over a 3.5- to 5-year period, there was no evidence of C-cell malignancies occurred in the liraglutide group [84]